In a world with an alternate history, a great war finally comes to an end leaving the earth diseased and polluted. The geneticist Dr. Azuma vies for support from the government for his neo-cell treatment that he claims can rejuvenate the body and regenerate humankind. The government leaders, guarding their own deeply entrenched powers, turn down the professor. Driven to complete his work, Dr. Azuma accepts a secret offer from a sinister faction of the powerful military. After an incident occurs in Dr. Azuma's lab, a race of mutant humans known as the Shinzo Ningen are unleashed upon the world. Now only the warrior known as Casshern, reincarnated with an invincible body, stands between the Shinzo Ningen and a world on the brink of annihilation.

Shou's father Norio finds his son in a rather meaningless existence in Tokyo dominated by alcohol and porn videos. Having left home two years earlier to pursue life as a musician, Shou has left his band and his girlfriend has left him. His father asks a favor, that Shou clean out the apartment of his aunt Matsuko, who he says led a meaningless life until her murder at the age of 53. The apartment is filled with garbage bags and is even more unkempt than his apartment has become, and he becomes intrigued with his aunt as details of her life are supplied by a tattooed neighbor and others. Her feelings of neglect by her father Tsunehiro, who favored her chronically ill younger sister, Kumi, translated into becoming a dutiful junior high school teacher devoted to her students until being forced to resign after being blamed for the theft of some money by one of them. Leaving her family due to the disgrace...

A city is ravaged by an epidemic of instant "white blindness". Those first afflicted are quarantined by the authorities in an abandoned mental hospital where the newly created "society of the blind" quickly breaks down. Criminals and the physically powerful prey upon the weak, hoarding the meager food rations and committing horrific acts. There is however one eyewitness to the nightmare. A woman whose sight is unaffected by the plague follows her afflicted husband to quarantine. There, keeping her sight a secret, she guides seven strangers who have become, in essence, a family. She leads them out of quarantine and onto the ravaged streets of the city, which has seen all vestiges of civilization crumble.